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This lecture introduces the topic of nanobiosensors for distributed diagnostics, emphasizing the need for circuit and system development to integrate these sensors into portable electronics. The historical perspective provided showcases the impact of biomedical circuits and systems on healthcare, highlighting breakthrough technologies and advancements over the past decade. The speaker discusses the importance of bridging engineering and biology, showcasing examples such as deep brain stimulation for Parkinson's disease and the potential for advancements in cancer treatment. The lecture also delves into the challenges and opportunities in developing wearable sensors, emphasizing the key factors of accuracy, sensitivity, and size. Various sensor interfaces and techniques to address noise and offset limitations are explored, with a focus on enhancing the performance of wearable devices.