Protein-protein Interaction Networks

This lecture delves into the significance of protein-protein interaction (PPI) networks in controlling cellular processes. By mapping PPIs across different organisms, the complexity and importance of these networks are highlighted. Experimental approaches, such as Tandem Affinity Purification and Peptide Sequencing by ESI-MSMS, are discussed to characterize PPI networks. The study of virus-host interactions, the scoring system for AP-MS, and the construction of PPI networks are also explored, emphasizing the biological relevance and implications of these interactions.