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This lecture introduces the concepts and technologies behind fragment-based drug discovery (FBDD). It covers the rule of three for fragment-based drug discovery, hit identification methods, and the application of FBDD in target-based drug discovery. The lecture also discusses the importance of sensitive screening methods in FBDD, common hit-to-lead routes, and case examples like Pexidartinib and Navitoclax. Additionally, it explores how FBDD is useful for both druggable and less druggable targets, providing insights into the development of small molecules for challenging protein-protein interactions.