Complex Stability

This lecture covers the stability of complexes, focusing on reactions of ligand fixation, stability constants, chelate effect, and thermodynamic aspects. Examples include silver-diamine complex, EDTA complexes with transition metals, and the use of EDTA in metal cation titrations. The instructor explains the concept of stability through enthalpic and entropic contributions, demonstrating the chelate effect in nickel complexes. The lecture also discusses the determination of water hardness using EDTA titrations and the application of chelating agents in medicine, such as iron chelators and EDTA derivatives. Various complexing agents like desferrioxamine and dexrazoxane are presented, along with their medical uses and mechanisms of action.