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This lecture covers gene transcription, regulation, and gene regulatory networks in the context of neuroscience research. It also discusses the experimental tools used, such as genomics, DNA sequencing techniques, and transcriptomics. The history of DNA sequencing advancements, including the development of long-read sequencing and RNA-sequencing, is presented. The Polymerase Chain Reaction (PCR) method for DNA amplification and sequencing is explained, along with its applications in research. The lecture concludes with the impact of the Patrick and Lina Drahi Foundation on supporting neuroscience education through MOOCs.