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This lecture explores the convergence of social and biological determinants of health in the context of personalised psychiatry, focusing on the impact of epigenetic biomarkers in stress-related diseases. It discusses the challenges of representing bio-psycho-social complexity, adapting public health interventions, and the implications for therapeutic approaches. The presentation delves into the intricate relationship between biology and biography, the plasticity of biological systems, and the temporalities of adaptations. It also examines the potential of epigenetics in reshaping the concept of biomarkers, the dynamic and multi-layered view of vulnerability/resilience to stress/trauma, and the importance of interventions in the social environment for mental health.