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This lecture covers the NASA Design Definition Process, Multidisciplinary Design Optimization, Concurrent Design Facilities (CDF), and Critical Design Review (CDR). It delves into the importance of design solution definition, multidisciplinary design optimization, and the challenges faced in system design optimization. The instructor discusses the roots and motivation behind Multidisciplinary Design Optimization, as well as the role of constraints in the design process. The lecture also explores the application of optimization techniques in the design of optimal structures, such as a soda can. Furthermore, it addresses the challenges and lessons learned in Concurrent Design Facilities (CDF) and the Critical Design Review (CDR) process.