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This lecture covers the principles and mechanisms of catalytic asymmetric reactions in organic chemistry, focusing on key topics such as Lewis and Brønsted acids activation of carbonyl and imines, Aldol Reaction, Allylation and Ene Reactions, and other nucleophiles for carbonyl addition. The instructor discusses important catalysts, applications, and the non-linear effect observed in some reactions. Various catalysts and their applications are explored, including the Keck allylation with Ti-Binol catalysts and the oxidation of products with ozone. The lecture also delves into the kinetic resolution of chiral compounds, desymmetrization, and the Mannich Reaction.