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This lecture covers the total synthesis of natural products, including classical examples, strategies like domino reactions and C-H functionalization, and the impact of total synthesis on science and society. It discusses the race to be the first in synthesis, the discovery of new reactions, serendipity in chemistry, and the structural determination of complex molecules. The lecture also explores how total synthesis has led to the development of new drugs, the solving of supply issues, and the creation of natural product-based drugs. It emphasizes the importance of total synthesis in deepening biological studies and as a learning process for synthetic chemists.