Intestine Organoids: Development and Applications

This lecture delves into the development of intestine organoids, focusing on the renewal process of the small intestine every three days, the identification of stem cells using LGR5 protein, and the challenges in replicating the complex structure of the intestine in vitro. The instructor explains the importance of the extracellular matrix and signaling molecules in guiding cell differentiation, showcasing a breakthrough experiment using a microfluidic system to create intestinal organoids with crypt-like structures. The potential applications of these organoids in studying interactions with pathogens and immune cells are also discussed.