Myc-Max: Protein Interactions and Cell Proliferation

This lecture covers the interactions between Myc, Max, and Miz proteins, their role in activating or inhibiting gene expression related to cell proliferation, and the impact on cell cycle progression. It explains how Myc activates gene expression by binding to Max, leading to the induction of various biological effects, such as cell proliferation and inhibition of apoptosis. The lecture also discusses the regulation of nucleotide metabolism genes by Myc, the control of microRNA expression, and the estimated percentage of the genome controlled by Myc-Max. Additionally, it delves into the transcriptional activities of Myc, its dual role as an activator and repressor, and the specific mechanisms through which it influences gene expression.