Myc-Max: Protein Interactions and Cell Proliferation

This lecture covers the interactions between Myc, Max, and Miz proteins, their role in activating or inhibiting gene expression related to cell proliferation, and the impact on cell cycle progression. It explains how Myc activates gene expression by binding to Max, leading to the induction of various biological effects, such as cell proliferation and inhibition of apoptosis. The lecture also discusses the regulation of nucleotide metabolism genes by Myc, the control of microRNA expression, and the estimated percentage of the genome controlled by Myc-Max. Additionally, it delves into the transcriptional activities of Myc, its dual role as an activator and repressor, and the specific mechanisms through which it influences gene expression.

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Related concepts (31)

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Transcriptional regulation

In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from altering the number of copies of RNA that are transcribed, to the temporal control of when the gene is transcribed. This control allows the cell or organism to respond to a variety of intra- and extracellular signals and thus mount a response.

Transcription (biology)

Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules called non-coding RNAs (ncRNAs). mRNA comprises only 1–3% of total RNA samples. Less than 2% of the human genome can be transcribed into mRNA (Human genome#Coding vs. noncoding DNA), while at least 80% of mammalian genomic DNA can be actively transcribed (in one or more types of cells), with the majority of this 80% considered to be ncRNA.

Transcription factor

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Histone acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression. In general, histone acetylation is linked to transcriptional activation and associated with euchromatin.

Histone deacetylase

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