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This lecture introduces Optical Coherence Tomography (OCT) as a non-invasive imaging technique used in various fields such as medical diagnostics and materials science. The instructor discusses the principles behind OCT, including Michelson Interferometry and different types of OCT like Time Domain and Fourier Domain. The lecture covers the applications of OCT in analyzing macular holes in the retina, imaging the human eye, and studying neurodegenerative diseases. Additionally, it explores the use of OCT in multi-resolution 3D microscopy and the growth of a-synuclein fibrils. Various concepts related to OCT, such as resolution, sample diameter, and different imaging techniques, are explained in detail.