Drug Targets: Ligand-Gated Ion Channels and Kinase-Linked Receptors

This lecture covers drug targets such as ligand-gated ion channels and kinase-linked receptors, including GABA receptors and the insulin receptor. It discusses the mechanisms of action of drugs at these receptors, clinical uses, unwanted effects, and the subunit composition of GABA receptors. The lecture also explores the subtype-specific roles of GABAA receptors, drug-induced sedation, amnesia, and anticonvulsant activity. Additionally, it delves into the physiological context of insulin, its receptor, and signaling pathways, as well as various pharmacological strategies for treating diabetes mellitus type 2.