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This lecture provides an introduction to carbohydrate, lipid, and protein metabolism, discussing the general energy balance, glycemic homeostasis over time, protein and amino acid requirements, and the role of the pancreas in glycemic homeostasis. It covers topics such as the insulin-receptor cellular interaction, fat storage influenced by insulin, and the control of blood glucose levels by Glucagon-like Peptide-1. Additionally, it explores the metabolism of amino acids, hormonal control of food intake and hunger, and the role of lipoprotein lipase in white adipose tissue. The lecture also delves into the mechanisms of insulin and glucagon in fatty acid and glucose metabolism, as well as the significance of glucagon in maintaining blood glucose levels.