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This lecture introduces the fundamentals of thermodynamics and chemical reactions, focusing on the energy transformations and the formation of molecules. Topics include the conservation of mass, stoichiometry, energy internal, and the principles of chemical reactions. The lecture also covers the classification of reactions, equilibrium, and the concept of energy conservation. Additionally, it explores the laws of perfect gases, internal energy, and the first law of thermodynamics, emphasizing the relationship between heat exchange, work, and energy conservation in closed systems.