This lecture explores the role of thermodynamics in cell biology, focusing on the connection between thermodynamics and cellular processes. It covers topics such as the universality of thermodynamics, classical mechanics, classical thermodynamics, and microscopic thermodynamics. The lecture delves into the concepts of equilibrium, idealizations in thermodynamics, and the predictions made by thermodynamics. It also discusses the importance of thermodynamics in understanding matter properties affected by temperature changes, the types of processes, work, internal energy, the first law of thermodynamics, reversible processes, and exact and inexact differentials.