Person
Pablo Jose Fernandez Marcos
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Related publications (5)
Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.
SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function
Carlos Canto Alvarez, Joanna Ratajczak, Pablo Jose Fernandez Marcos
Objective: SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective against diverse metabolic complications, especially in response to high-fat diets ...
Elsevier Science Bv2015Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Pénélope Andreux, Norman Lionel Moullan, Eija Riitta Pirinen, Hiroyasu Yamamoto, Taoufiq Harach, Pablo Jose Fernandez Marcos, Ellen Helena Jeninga
Sirt3 is a mitochondrial sirtuin, predominantly expressed in highly metabolic tissues. Germline ablation of Sirt3 has major metabolic consequences, including increased susceptibility to metabolic damage and oxidative stress after high fat feeding. In order ...
2012The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Pénélope Andreux, Karl Gademann, Richardus Houtkooper, Eija Riitta Pirinen, Hiroyasu Yamamoto, Maaike Hélène Oosterveer, Pablo Jose Fernandez Marcos
As NAD(+) is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line with this premise, decreased activity of PARP-1 or CD38-both NAD(+ ...
Elsevier2012