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A divergent and regiocontrolled Pd-catalyzed domino sequence involving an intramol. N-arylation and an intermol. Heck reaction has been developed, providing rapid access to functionalized benzodiazepine-2,5-diones, e.g. I. The starting materials were synthesized by the Ugi four-component reaction. An unprecedented X-ray structure of a bispalladacycle was documented. [on SciFinder (R)]
Jérôme Waser, Raphaël Michel Henri Simonet-Davin, Emmanuelle Madeline Dominique Allouche
Rosario Scopelliti, Marinella Mazzanti, Marta Falcone, Nadir Jori