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Publication
Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
Bone defects in revision knee arthroplasty (RKA) are often located in load-bearing regions. The goal of this study was to determine if a physiologic load could be used as an in situ osteogenic signal to the scaffolds filling the bone defects. In order to answer this question, we proposed a novel translation procedure having four steps: 1) Determining the mechanical stimulus using FEM, 2) Designing an animal study to measure bone formation spatially and temporally using micro-CT imaging in the scaffold subjected to the estimated mechanical stimulus, 3) Identifying bone formation parameters for the loaded and non-loaded cases appearing in a recently developed mathematical model for bone formation in scaffold, and 4) Estimation of stiffness and the bone formation in the bone-scaffold construct. With this procedure, we estimated that after three years mechanical stimulation increases the bone volume fraction and the stiffness of scaffold by 1.5-fold, and 2.7-fold, respectively.