Publication
We report here a dehydropeptidase-deficient murine model of tuberculosis (TB) infection that is able to partially uncover the efficacy of marketed broad-spectrum beta-lactam antibiotics alone and in combination. Reductions of up to 2 log CFU in the lungs of TB-infected mice after 8 days of treatment compared to untreated controls were obtained at blood drug concentrations and time above the MIC (T->MIC) below clinically achievable levels in humans. These findings provide evidence supporting the potential of beta-lactams as safe and mycobactericidal components of new combination regimens against TB with or without resistance to currently used drugs.
Camille Véronique Bernadette Goemans, Florian Huber
Sandor Kasas, María Inés Villalba
César Pulgarin, Stefanos Giannakis, Truong-Thien Melvin Le, Jérémie Decker