Publication
Apparent compensation mechanisms in relatives of schizophrenia patients in visual backward masking
Michael Herzog, Maya Roinishvili, Patricia Figueiredo, Janir Nuno Ramos Antunes Da Cruz
2016
Conference paper
2016
Conference paper
Abstract
Visual backward masking (VBM) is strongly deteriorated in schizophrenia patients. VBM is a potential endophenotype of schizophrenia reflecting the genetic underpinnings of the disease (Chkonia et al., 2010). Masking deficits are highly correlated with reduced N1 amplitudes as shown by the Global Field Power (GFP; Plomp et al., 2013). Here, we investigated the electrophysiological correlates of VBM in first-order relatives of schizophrenia patients.
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Related concepts (16)
Schizophrenia
Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdrawal, and flat affect. Symptoms typically develop gradually, begin during young adulthood, and in many cases never become resolved. There is no objective diagnostic test; diagnosis is based on observed behavior, a psychiatric history that includes the person's reported experiences, and reports of others familiar with the person.
N100
In neuroscience, the N100 or N1 is a large, negative-going evoked potential measured by electroencephalography (its equivalent in magnetoencephalography is the M100); it peaks in adults between 80 and 120 milliseconds after the onset of a stimulus, and is distributed mostly over the fronto-central region of the scalp. It is elicited by any unpredictable stimulus in the absence of task demands. It is often referred to with the following P200 evoked potential as the "N100-P200" or "N1-P2" complex.
N400 (neuroscience)
The N400 is a component of time-locked EEG signals known as event-related potentials (ERP). It is a negative-going deflection that peaks around 400 milliseconds post-stimulus onset, although it can extend from 250-500 ms, and is typically maximal over centro-parietal electrode sites. The N400 is part of the normal brain response to words and other meaningful (or potentially meaningful) stimuli, including visual and auditory words, sign language signs, pictures, faces, environmental sounds, and smells.
Related publications (30)
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Visual backward masking (VBM) deficits are candidate endophenotypes of schizophrenia indexing genetic liability of the disorder. In VBM, a target is followed by a mask that deteriorates target perception. Schizophrenia patients and, to a lesser extent, the ...
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