Single-photon avalanche diode imaging sensor for subsurface fluorescence LiDAR

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü
2021
Journal paper

Abstract

We realized subsurface fluorescence LiDAR with a large format single-photon avalanche diode array capable of localizing and quantifying concentration of fluorescent molecules in heavily scattering media, such as tissue, with submillimeter depth accuracy. (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Official source

https://infoscience.epfl.ch/record/288498?ln=en

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Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü
2021
Journal paper

Abstract

Official source

https://infoscience.epfl.ch/record/288498?ln=en

About this result

Ontological neighbourhood

Chemistry

Physical chemistry: Fluorescence imaging

Related concepts (8)

In molecular biology and biotechnology, a fluorescent tag, also known as a fluorescent label or fluorescent probe, is a molecule that is attached chemically to aid in the detection of a biomolecule such as a protein, antibody, or amino acid. Generally, fluorescent tagging, or labeling, uses a reactive derivative of a fluorescent molecule known as a fluorophore. The fluorophore selectively binds to a specific region or functional group on the target molecule and can be attached chemically or biologically.

A fluorescence microscope is an optical microscope that uses fluorescence instead of, or in addition to, scattering, reflection, and attenuation or absorption, to study the properties of organic or inorganic substances. "Fluorescence microscope" refers to any microscope that uses fluorescence to generate an image, whether it is a simple set up like an epifluorescence microscope or a more complicated design such as a confocal microscope, which uses optical sectioning to get better resolution of the fluorescence image.

The green fluorescent protein (GFP) is a protein that exhibits bright green fluorescence when exposed to light in the blue to ultraviolet range. The label GFP traditionally refers to the protein first isolated from the jellyfish Aequorea victoria and is sometimes called avGFP. However, GFPs have been found in other organisms including corals, sea anemones, zoanithids, copepods and lancelets. The GFP from A. victoria has a major excitation peak at a wavelength of 395 nm and a minor one at 475 nm.

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