Publication

Deracemization of 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH): practical synthesis of (-)-(S)-HPPH

Pierre Vogel
2004
Journal paper

Abstract

In the presence of 10% NaOH in boiling MeOH enantiomerically enriched HPPH is racemized. This permits the deracemization of HPPH in the presence of brucine, giving enantiomerically pure (-)-(S)-HPPH [(-)-(S)-5-(4-hydroxyphenyl)-5-phenylhydandoin]. (C) 2004 Elsevier Ltd. All rights reserved.

Official source

https://infoscience.epfl.ch/record/59767?ln=en

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Deracemization of 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH): practical synthesis of (-)-(S)-HPPH

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