Publication
Continuous production of lactic acid from whey permeate by Lactobacillus helveticus in two chemostats in series
Abstract
The effect of diln. rate on the prodn. of lactic acid from whey permeate by L. helveticus was investigated. In the 1st chemostat of a 2-stage system, total conversion (98.1%) and max. lactic acid concn. (43.7 g/L) were obtained at a diln. rate (D1tot) of 0.06/h. Max. volumetric productivities of lactic acid (8.27 g/L-h) and biomass (1.90 g/L-h) occurred at D1tot of 0.40/h. The fraction of L-lactate in the product increased with diln. rate and reached a max. of 66% at the same diln. rate. The max. sp. growth rate (mmax) on this medium was 0.7/h. A YATP(max) value of 22.4 g dry wt./mol ATP and a maintenance coeff. of 8.0 mmol ATP/g dry wt.-h were detd. The 2nd stage, in series with the 1st, confirmed these results and also showed that the total residence time could be reduced by 50% compared with a single chemostat for the same nearly complete level of substrate conversion. [on SciFinder (R)]
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Related concepts (33)
Lactic acid
Lactic acid is an organic acid. It has a molecular formula . It is white in the solid state and it is miscible with water. When in the dissolved state, it forms a colorless solution. Production includes both artificial synthesis as well as natural sources. Lactic acid is an alpha-hydroxy acid (AHA) due to the presence of a hydroxyl group adjacent to the carboxyl group. It is used as a synthetic intermediate in many organic synthesis industries and in various biochemical industries.
Adenosine triphosphate
Adenosine triphosphate (ATP) is an organic compound that provides energy to drive and support many processes in living cells, such as muscle contraction, nerve impulse propagation, condensate dissolution, and chemical synthesis. Found in all known forms of life, ATP is often referred to as the "molecular unit of currency" of intracellular energy transfer. When consumed in metabolic processes, it converts either to adenosine diphosphate (ADP) or to adenosine monophosphate (AMP). Other processes regenerate ATP.
Lactic acidosis
Lactic acidosis is a medical condition characterized by a build-up of lactate (especially -lactate) in the body, with formation of an excessively low pH in the bloodstream. It is a form of metabolic acidosis, in which excessive acid accumulates due to a problem with the body's oxidative metabolism. Lactic acidosis is typically the result of an underlying acute or chronic medical condition, medication, or poisoning. The symptoms are generally attributable to these underlying causes, but may include nausea, vomiting, Kussmaul breathing (laboured and deep), and generalised weakness.
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