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Concept
Degenerative disease
Summary
Degenerative disease is the result of a continuous process based on degenerative cell changes, affecting tissues or organs, which will increasingly deteriorate over time.
In neurodegenerative diseases, cells of the central nervous system stop working or die via neurodegeneration. An example of this is Alzheimer's disease. The other two common groups of degenerative diseases are those that affect circulatory system (e.g. coronary artery disease) and neoplastic diseases (e.g. cancers).
Many degenerative diseases exist and some are related to aging. Normal bodily wear or lifestyle choices (such as exercise or eating habits) may worsen degenerative diseases, but this depends on the disease. Sometimes the main or partial cause behind such diseases is genetic. Thus some are clearly hereditary like Huntington's disease. Sometimes the cause is viruses, poisons or other chemicals. The cause may also be unknown.
Some degenerative diseases can be cured. In those that can not, it may be possible to alleviate the symptoms.
Alzheimer's disease (AD)
Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease)
Cancers
Charcot–Marie–Tooth disease (CMT)
Chronic traumatic encephalopathy
Cystic fibrosis
Some cytochrome c oxidase deficiencies (often the cause of degenerative Leigh syndrome)
Ehlers–Danlos syndrome
Fibrodysplasia ossificans progressiva
Friedreich's ataxia
Frontotemporal dementia (FTD)
Some cardiovascular diseases (e.g. atherosclerotic ones like coronary artery disease, aortic stenosis, congenital defects etc.)
Huntington's disease
Infantile neuroaxonal dystrophy
Keratoconus (KC)
Keratoglobus
Leukodystrophies
Macular degeneration (AMD)
Marfan's syndrome (MFS)
Some mitochondrial myopathies
Mitochondrial DNA depletion syndrome
Mueller–Weiss syndrome
Multiple sclerosis (MS)
Multiple system atrophy
Muscular dystrophies (MD)
Neuronal ceroid lipofuscinosis
Niemann–Pick diseases
Osteoarthritis
Osteoporosis
Parkinson's disease
Pulmonary arterial hypertension
All prion diseases (Creutzfeldt-Jakob disease, fatal familial insomnia etc.
Official source
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