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Supramolecular chemistry

Supramolecular chemistry refers to the branch of chemistry concerning chemical systems composed of a discrete number of molecules. The strength of the forces responsible for spatial organization of the system range from weak intermolecular forces, electrostatic charge, or hydrogen bonding to strong covalent bonding, provided that the electronic coupling strength remains small relative to the energy parameters of the component. While traditional chemistry concentrates on the covalent bond, supramolecular chemistry examines the weaker and reversible non-covalent interactions between molecules. These forces include hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, pi–pi interactions and electrostatic effects. Important concepts advanced by supramolecular chemistry include molecular self-assembly, molecular folding, molecular recognition, host–guest chemistry, mechanically-interlocked molecular architectures, and dynamic covalent chemistry. The study of non-covalent interactions is crucial to understanding many biological processes that rely on these forces for structure and function. Biological systems are often the inspiration for supramolecular research. file:Supramolecular Assembly Lehn.jpg |Self-assembly of a circular double helicate{{Cite journal | doi = 10.1002/anie.199618381| title = Self-Assembly of a Circular Double Helicate| journal = Angewandte Chemie International Edition in English| volume = 35| issue = 16| pages = 1838–1840| year = 1996| last1 = Hasenknopf | first1 = B. | last2 = Lehn | first2 = J. M. | last3 = Kneisel | first3 = B. O. | last4 = Baum | first4 = G. | last5 = Fenske | first5 = D.}} Cucurbituril gyroscope AngewChemIntEd 2002 v41 p275 hires.png|Host–guest complex within another host ([[cucurbituril]]){{Cite journal | doi = 10.1002/1521-3773(20020118)41:23.0.CO;2-M| title = A Cucurbituril-Based Gyroscane: A New Supramolecular Form| journal = Angewandte Chemie International Edition| volume = 41| issue = 2| pages = 275–7| year = 2002| last1 = Day | first1 = A.

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Molecular self-assembly
In chemistry and materials science, molecular self-assembly is the process by which molecules adopt a defined arrangement without guidance or management from an outside source. There are two types of self-assembly: intermolecular and intramolecular. Commonly, the term molecular self-assembly refers to the former, while the latter is more commonly called folding. Molecular self-assembly is a key concept in supramolecular chemistry. This is because assembly of molecules in such systems is directed through non-covalent interactions (e.
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