Domestication is a multi-generational relationship between humans and other organisms, where humans take control over their reproduction and care to have a steady supply of the organisms' resources. It can be argued that domestication is a form of mutualism, where both humans and the organisms are benefited. The domestication of plants and animals by humans was a major cultural innovation ranked in importance with the conquest of fire, the manufacturing of tools, and the development of verbal language. Charles Darwin recognized the small number of traits that made domestic species different from their wild ancestors. He was also the first to recognize the difference between conscious selective breeding (i.e. artificial selection) in which humans directly select for desirable traits, and unconscious selection where traits evolve as a by-product of natural selection or from selection on other traits. There is a genetic difference between domestic and wild populations. There is also such a difference between the domestication traits that researchers believe to have been essential at the early stages of domestication, and the improvement traits that have appeared since the split between wild and domestic populations. Domestication traits are generally fixed within all domesticates, and were selected during the initial episode of domestication of that animal or plant, whereas improvement traits are present only in a proportion of domesticates, though they may be fixed in individual breeds or regional populations. The dog was the first domesticated species, and was established across Eurasia before the end of the Late Pleistocene era, well before cultivation and the domestication of other animals. The archaeological and genetic data suggest that long-term bidirectional gene flow between wild and domestic stocks – including donkeys, horses, New and Old World camelids, goats, sheep, and pigs – was common.

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