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Concept
Hematologic disease
Summary
Hematologic diseases are disorders which primarily affect the blood & blood-forming organs. Hematologic diseases include rare genetic disorders, anemia, HIV, sickle cell disease & complications from chemotherapy or transfusions.
Hemoglobinopathies (congenital abnormality of the hemoglobin molecule or of the rate of hemoglobin synthesis)
Sickle cell disease
Thalassemia
Methemoglobinemia
Anemias (lack of red blood cells or hemoglobin)
Iron-deficiency anemia
Megaloblastic anemia
Vitamin B12 deficiency
Pernicious anemia
Folate deficiency
Hemolytic anemias (destruction of red blood cells)
Genetic disorders of RBC membrane
Hereditary spherocytosis
Hereditary elliptocytosis
Congenital dyserythropoietic anemia
Genetic disorders of RBC metabolism
Glucose-6-phosphate dehydrogenase deficiency (G6PD)
Pyruvate kinase deficiency
Immune mediated hemolytic anemia (direct Coombs test is positive)
Autoimmune hemolytic anemia
Warm antibody autoimmune hemolytic anemia
Idiopathic
Systemic lupus erythematosus (SLE)
Evans syndrome (antiplatelet antibodies and hemolytic antibodies)
Cold autoimmune hemolytic anemia
Cold agglutinin disease
Paroxysmal cold hemoglobinuria (rare)
Infectious mononucleosis
Alloimmune hemolytic anemia
Hemolytic disease of the newborn (HDN)
Rh disease (Rh D)
ABO hemolytic disease of the newborn
Anti-Kell hemolytic disease of the newborn
Rhesus c hemolytic disease of the newborn
Rhesus E hemolytic disease of the newborn
Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
Drug induced immune mediated hemolytic anemia
Penicillin (high dose)
Methyldopa
Hemoglobinopathies (where these is an unstable or crystalline hemoglobin)
Paroxysmal nocturnal hemoglobinuria (rare acquired clonal disorder of red blood cell surface proteins)
Direct physical damage to RBCs
Microangiopathic hemolytic anemia
Secondary to artificial heart valve(s)
Aplastic anemia
Fanconi anemia
Diamond–Blackfan anemia (inherited pure red cell aplasia)
Acquired pure red cell aplasia
Decreased numbers of cells
Myelodysplastic syndr
Official source
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