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In cellular biology, a somatic cell (), or vegetal cell, is any biological cell forming the body of a multicellular organism other than a gamete, germ cell, gametocyte or undifferentiated stem cell. Such cells compose the body of an organism and divide through the process of binary fission and mitotic division. In contrast, gametes are cells that fuse during sexual reproduction, germ cells are cells that give rise to gametes, and stem cells are cells that can divide through mitosis and differentiate into diverse specialized cell types. For example, in mammals, somatic cells make up all the internal organs, skin, bones, blood and connective tissue, while mammalian germ cells give rise to spermatozoa and ova which fuse during fertilization to produce a cell called a zygote, which divides and differentiates into the cells of an embryo. There are approximately 220 types of somatic cell in the human body. Theoretically, these cells are not germ cells (the source of gametes); they transmit their mutations, to their cellular descendants (if they have any), but not to the organism's descendants. However, in sponges, non-differentiated somatic cells form the germ line and, in Cnidaria, differentiated somatic cells are the source of the germline. Mitotic cell division is only seen in diploid somatic cells. Only some cells like germ cells take part in reproduction. As multicellularity evolved many times, so did sterile somatic cells. The evolution of an immortal germline producing specialized somatic cells involved the emergence of mortality, and can be viewed in its simplest version in volvocine algae. Those species with a separation between sterile somatic cells and a germline are called Weismannists. Weismannist development is relatively rare (e.g., vertebrates, arthropods, Volvox), as many species have the capacity for somatic embryogenesis (e.g., land plants, most algae, and numerous invertebrates). Like all cells, somatic cells contain DNA arranged in chromosomes.

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