Wuhu () is a prefecture-level city in southeastern Anhui province, China. Sitting on the southeast bank of the Yangtze River, Wuhu borders Xuancheng to the southeast, Chizhou and Tongling to the southwest, Hefei City to the northwest, Ma'anshan city to the northeast, Jiangsu to the east, and is approximately southwest of Nanjing. With the urbanization trend in the southern part of Nanjing, a conurbation between Nanjing, Maanshan and Wuhu is in building with more than 10,660,000 inhabitants.
Wuhu is known to have been inhabited since at least 570 BCE. Present-day Wuhu evolved out of a settlement known as Jiuzi (), located on the southern bank of the Shuiyang River, about southeast of Wuhu's contemporary urban core. Jiuzi was a site of conflict prior to 670 BCE between the Chu and the Wu during the Spring and Autumn period. In 473 BCE, the Yue took Jiuzi from the Wu. In 306 BCE, the Chu took Jiuzi from the Yue.
During the time of the Qin dynasty, Jiuzi was placed under the jurisdiction of the Zhang Commandery (). In 109 BCE, Zhang Commandery was renamed to zh. During this time, the area of Juizi was reorganized as Wuhu County (). In 223 CE, under the reign of Sun Quan of the Eastern Wu, the county seat was moved from the site of Jiuzi to the highlands along the north banks of the Qingyi River, to the southeast of contemporary Wuhu's urban core.
zh was carved-out of Danyang Commandery in 281 CE, with the headquarters of Danyang Commandery moved to Nanjing. The area of contemporary Wuhu remained under the jurisdiction of Danyang Commandery. During the Eastern Jin period, the area saw an influx of people migrate to the area from the Central Plains. The area was placed under the jurisdiction of Xuancheng Commandery in 363 CE, and the commandery's headquarters were moved to the area. During the late 4th Century, the area underwent a number of other administrative changes. Part of the area would fall under the jurisdiction of zh.
Both Xuancheng Commandery and Huainan Commandery were abolished early on during the Sui dynasty, in 589 CE.