Potassium bromide (KBr) is a salt, widely used as an anticonvulsant and a sedative in the late 19th and early 20th centuries, with over-the-counter use extending to 1975 in the US. Its action is due to the bromide ion (sodium bromide is equally effective). Potassium bromide is used as a veterinary drug, as an antiepileptic medication for dogs.
Under standard conditions, potassium bromide is a white crystalline powder. It is freely soluble in water; it is not soluble in acetonitrile. In a dilute aqueous solution, potassium bromide tastes sweet, at higher concentrations it tastes bitter, and tastes salty when the concentration is even higher. These effects are mainly due to the properties of the potassium ion—sodium bromide tastes salty at any concentration. In high concentration, potassium bromide strongly irritates the gastric mucous membrane, causing nausea and sometimes vomiting (a typical effect of all soluble potassium salts).
Potassium bromide, a typical ionic salt, is fully dissociated and near pH 7 in aqueous solution. It serves as a source of bromide ions. This reaction is important for the manufacture of silver bromide for photographic film:
KBr_{(aq)}{} + AgNO3_{(aq)} -> AgBr_{(s)}{} + KNO3_{(aq)}
Aqueous bromide also forms complexes when reacted with some metal halides such as copper(II) bromide:
2 KBr_{(aq)}{} + CuBr2_{(aq)} -> K2[CuBr3]_{(aq)}
A traditional method for the manufacture of KBr is the reaction of potassium carbonate with an iron(III, II) bromide, , made by treating scrap iron under water with excess bromine:
4 K2CO3 + Fe3Br8 -> 8 KBr + Fe3O4 + 4 CO2
The anticonvulsant properties of potassium bromide were first noted by Sir Charles Locock at a meeting of the Royal Medical and Chirurgical Society in 1857. Bromide can be regarded as the first effective medication for epilepsy. At the time, it was commonly thought that epilepsy was caused by masturbation. Locock noted that bromide calmed sexual excitement and thought this was responsible for his success in treating seizures.
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A bromide ion is the negatively charged form (Br−) of the element bromine, a member of the halogens group on the periodic table. Most bromides are colorless. Bromides have many practical roles, being found in anticonvulsants, flame-retardant materials, and cell stains. Although uncommon, chronic toxicity from bromide can result in bromism, a syndrome with multiple neurological symptoms. Bromide toxicity can also cause a type of skin eruption, see potassium bromide. The bromide ion has an ionic radius of 196 pm.
Sodium bromide is an inorganic compound with the formula NaBr. It is a high-melting white, crystalline solid that resembles sodium chloride. It is a widely used source of the bromide ion and has many applications. NaBr crystallizes in the same cubic motif as NaCl, NaF and NaI. The anhydrous salt crystallizes above 50.7 °C. Dihydrate salts (NaBr·2H2O) crystallize out of water solution below 50.7 °C. NaBr is produced by treating sodium hydroxide with hydrogen bromide. Sodium bromide can be used as a source of the chemical element bromine.
Phenobarbital, also known as phenobarbitone or phenobarb, sold under the brand name Luminal among others, is a medication of the barbiturate type. It is recommended by the World Health Organization (WHO) for the treatment of certain types of epilepsy in developing countries. In the developed world, it is commonly used to treat seizures in young children, while other medications are generally used in older children and adults. In developed countries it is used for veterinary purposes.
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