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Concept
Oral administration
Summary
Oral administration is a route of administration whereby a substance is taken through the mouth, swallowed, and then processed via the digestive system. This is a common route of administration for many medications.
Oral administration can be easier and less painful than other routes of administration, such as injection. However, the onset of action is relatively low, and the effectiveness is reduced if it is not absorbed properly in the digestive system, or if it is broken down by digestive enzymes before it can reach the bloodstream. Some medications may cause gastrointestinal side effects, such as nausea or vomiting, when taken orally. Oral administration can also only be applied to conscious patients, and patients able to swallow.
Per os (ˌpɜrˈoʊs; P.O.) is an adverbial phrase meaning literally from Latin "through the mouth" or "by mouth". The expression is used in medicine to describe a treatment that is taken orally (but not used in the mouth such as, for example, caries prophylaxis). The abbreviation P.O. is often used on medical prescriptions.
Oral administration includes:
Buccal, dissolved inside the cheek
Sublabial, dissolved under the lip
Sublingual administration (SL), dissolved under the tongue, but due to rapid absorption many consider SL a parenteral route
Enteral medications come in various forms, including oral solid dosage (OSD) forms:
Tablets to swallow, chew or dissolve in water or under the tongue
Capsules and chewable capsules (with a coating that dissolves in the stomach or bowel to release the medication there)
Time-release or sustained-release tablets and capsules (which release the medication gradually)
Powders or granules
and oral liquid dosage forms:
Teas
Drops
Liquid medications or syrups
Concomitant ingestion of water facilitates in swallowing tablets and capsules. If the substance has disagreeable taste, addition of a flavor may facilitate ingestion. Substances that are harmful to the teeth are preferably given through a straw.
Official source
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