The GloFish is a patented and trademarked brand of fluorescently colored genetically modified fish. They have been created from several different species of fish: zebrafish (Danio rerio) were the first GloFish available in pet stores, and recently tetra (Gymnocorymbus ternetzi), tiger barbs (Puntius tetrazona), Rainbow Shark (Epalzeorhynchos frenatum), Siamese fighting fish (Betta splendens), and most recently Bronze corydoras (Corydoras aeneus) have been added to the lineup. They are sold in many colors, trademarked as "Starfire Red", "Moonrise Pink", "Sunburst Orange", "Electric Green", "Cosmic Blue", and "Galactic Purple", although not all species are available in all colors. Although not originally developed for the ornamental fish trade, it is one of the first genetically modified animals to become publicly available. The rights to GloFish are owned by Spectrum Brands, Inc., which purchased GloFish from Yorktown Technologies, the original developer of GloFish, in May 2017.
The original zebrafish (or zebra danio, Danio rerio) is a native of rivers in India and Bangladesh. It measures three centimeters long and has gold and dark blue stripes. In 1999, Dr. Zhiyuan Gong and his colleagues at the National University of Singapore were working with a gene that encodes the green fluorescent protein (GFP), originally extracted from a jellyfish, that naturally produced bright green fluorescence. They inserted the gene into a zebrafish embryo, allowing it to integrate into the zebrafish's genome, which caused the fish to be brightly fluorescent under both natural white light and ultraviolet light. Their goal was to develop a fish that could detect pollution by selectively fluorescing in the presence of environmental toxins. The development of the constantly fluorescing fish was the first step in this process, and the National University of Singapore filed a patent application on this work. Shortly thereafter, his team developed a line of red fluorescent zebra fish by adding a gene from a sea coral, and orange-yellow fluorescent zebra fish, by adding a variant of the jellyfish gene.