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In nuclear physics and nuclear chemistry, a nuclear reaction is a process in which two nuclei, or a nucleus and an external subatomic particle, collide to produce one or more new nuclides. Thus, a nuclear reaction must cause a transformation of at least one nuclide to another. If a nucleus interacts with another nucleus or particle and they then separate without changing the nature of any nuclide, the process is simply referred to as a type of nuclear scattering, rather than a nuclear reaction. In principle, a reaction can involve more than two particles colliding, but because the probability of three or more nuclei to meet at the same time at the same place is much less than for two nuclei, such an event is exceptionally rare (see triple alpha process for an example very close to a three-body nuclear reaction). The term "nuclear reaction" may refer either to a change in a nuclide induced by collision with another particle or to a spontaneous change of a nuclide without collision. Natural nuclear reactions occur in the interaction between cosmic rays and matter, and nuclear reactions can be employed artificially to obtain nuclear energy, at an adjustable rate, on-demand. Nuclear chain reactions in fissionable materials produce induced nuclear fission. Various nuclear fusion reactions of light elements power the energy production of the Sun and stars. In 1919, Ernest Rutherford was able to accomplish transmutation of nitrogen into oxygen at the University of Manchester, using alpha particles directed at nitrogen 14N + α → 17O + p. This was the first observation of an induced nuclear reaction, that is, a reaction in which particles from one decay are used to transform another atomic nucleus. Eventually, in 1932 at Cambridge University, a fully artificial nuclear reaction and nuclear transmutation was achieved by Rutherford's colleagues John Cockcroft and Ernest Walton, who used artificially accelerated protons against lithium-7, to split the nucleus into two alpha particles.
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