Category
Biomedical engineering
Related publications (1,000)
Exploration and modulation of mechanical cues for enhanced cancer immunotherapy
The advent of immunotherapy, such as immune checkpoint blockade (ICB) and adoptive transfer of cytotoxic lymphocytes, has transformed the clinical care of cancer. However, a significant proportion of patients are resistant to immunotherapy or experience re ...
EPFL2024Exploring the role of cGAS-STING-mediated inflammation in age-associated neurodegeneration and antitumor immunity
Inflammation stands as a dynamic and intricate biological process, promoting vital defence mechanisms against harmful stimuli, including infections and injuries, to drive pathogen clearance and healing. On one hand, these responses can manifest acutely and ...
EPFL2024Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization
Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...
EPFL2024Il-21 fusion proteins useful as enhancers of anti-cancer immunotherapies
The present invention relates generally to the field of anti-cancer therapy, in particular to the use of agents or co-agents useful in anti-cancer immunotherapy such as adoptive T-cell transfer (ACT) immunotherapy and immune check-point blockades. ...
2024An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading
We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit a ...
Berlin2024Advancing Cell-Free Synthetic Biology: From sustained PURE protein synthesis to an isothermal one-pot DNA replication system
One of the goals of synthetic biology is the development of an artificial cell. Building an artificial cell from scratch will provide a deeper understanding of fundamental mechanisms and models in biology and promises to contribute towards building novel p ...
EPFL2024Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth
Freddy Radtke, Nadine Fournier, Etienne Meylan, Justine Pascual, Amber Dawn Bowler, Anita Bodac, Vincent Roh
Elevated peripheral blood and tumor-infiltrating neutrophils are often associated with a poor patient prognosis. However, therapeutic strategies to target these cells are difficult to implement due to the life-threatening risk of neutropenia. In a genetica ...
Springernature2024Next-Generation Modeling of Cancer Using Organoids
Wouter Richard Karthaus, Jillian Rose Love
In the last decade, organoid technology has become a cornerstone in cancer research. Organoids are long-term primary cell cultures, usually of epithelial origin, grown in a three-dimensional (3D) protein matrix and a fully defined medium. Organoids can be ...
Cold Spring Harbor Lab Press, Publications Dept202433.3 MiBMI: A 192/512-Channel 2.46mm² Miniaturized Brain-Machine Interface Chipset Enabling 31-Class Brain-to-Text Conversion Through Distinctive Neural Codes
Mahsa Shoaran, Uisub Shin, Gregor Rainer, Mohammad Ali Shaeri, Amitabh Yadav
Recently, cutting-edge brain-machine interfaces (BMIs) have revealed the potential of decoders such as recurrent neural networks (RNNs) in predicting attempted handwriting [1] or speech [2], enabling rapid communication recovery after paralysis. However, c ...
IEEE2024Bioengineered Tubular Biliary Organoids
Matthias Lütolf, Bilge Sen Elçi, Saba Rezakhani, Mikhail Nikolaev
Liver organoids have emerged as promising in vitro models for toxicology, drug discovery, and disease modeling. However, conventional 3D epithelial organoid culture systems suffer from significant drawbacks, including limited culture duration, a nonphysiol ...
Hoboken2024