Cytoskeleton

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Dynamics of a flexible helical filament rotating in a viscous fluid near a rigid boundary

Pedro Miguel Nunes Pereira de Almeida Reis

We study the effect of a no-slip rigid boundary on the dynamics of a flexible helical filament rotating in a viscous fluid, at low Reynolds number conditions (Stokes limit). This system is taken as a reduced model for the propulsion of uniflagellar bacteri ...

2017

Cell-cell and cell-matrix interactions are essential to the survival and proliferation of most cells, and are responsible for triggering a wide range of biochemical pathways. More recently, the biomechanical role of those interactions was highlighted, show ...

Iop Publishing Ltd2017

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Pathogenicity of Mycobacterium tuberculosis (M. tb) is mediated by the ESX-1 secretion system, which exports EsxA and EsxB, the major virulence factors that are co-secreted with EspA and EspC. Functional information about ESX-1 components is scarce. Here, ...

2017

In eukaryotic cells, motor proteins (MPs) bind to cytoskeletal filaments and move along them in a directed manner generating active stresses. During cell division a spindle structure of overlapping antiparallel microtubules forms whose stability and dynami ...

Royal Soc Chemistry2017

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The intestine of fish is a multifunctional organ: lined by only a single layer of specialized epithelial cells, it has various physiological roles including nutrient absorption and ion regulation. It moreover comprises an important barrier for environmenta ...

Springer2017

Despite decades of research in Alzheimerâs disease (AD), no treatment has been found to efficiently prevent or cure its progression. The microtubule binding protein Tau plays central roles in the pathogenesis of AD and is found, in the form of paired hel ...

EPFL2017

La bourgeoisie de Pigalle

Ce projet propose une réinterprétation du modèle d'habitation bourgeois du XIXe siècle dans une ville qui s'est entièrement construite sur ce modèle, Paris. Situé dans le quartier de Pigalle, le projet tire profit du potentiel urbain de deux pointes d'îlot ...

2017

A Robust Actin Filaments Image Analysis Framework

Giovanni Dietler, Sandor Kasas

The cytoskeleton is a highly dynamical protein network that plays a central role in numerous cellular physiological processes, and is traditionally divided into three components according to its chemical composition, i.e. actin, tubulin and intermediate fi ...

Public Library of Science2016

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Actin-myosin filament bundles (stress fibers) are critical for tension generation and cell shape, but their mechanical properties are difficult to access. Here we propose a novel approach to probe individual peripheral stress fibers in living cells through ...

Nature Publishing Group2016

Bicyclic peptides are an attractive molecule format for the development of therapeutics and research tools. Our laboratory is specialized on the development of bicyclic peptide ligands by phage display. In brief, libraries of randompeptides each containing ...

EPFL2016