Person
Jan Lars Rybniker
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Related publications (13)
Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.
EspC forms a filamentous structure in the cell envelope of Mycobacterium tuberculosis and impacts ESX-1 secretion
Stewart Cole, Claudia Sala, Jan Lars Rybniker, Ye Lou
Pathogenicity of Mycobacterium tuberculosis (M. tb) is mediated by the ESX-1 secretion system, which exports EsxA and EsxB, the major virulence factors that are co-secreted with EspA and EspC. Functional information about ESX-1 components is scarce. Here, ...
2017Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria
Stewart Cole, Kai Johnsson, John McKinney, Graham Knott, Neeraj Dhar, Ruben Hartkoorn, Anthony Vocat, Gaëlle Séraphine Kolly, Jan Lars Rybniker, Edina Rita Székely, François Signorino-Gelo, Isabella Santi, Monica Rengifo Gonzalez
There is an urgent need to discover new antitubercular agents with novel mechanisms of action in order to tackle the scourge of drug-resistant tuberculosis. Here, we report the identification of such a molecule - an AminoPYrimidine-Sulfonamide (APYS1) that ...
Wiley-Blackwell2017Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis
Stewart Cole, Stefanie Boy-Röttger, Claudia Sala, Jérémie Piton, Gaëlle Séraphine Kolly, Joao Pedro De Almeida Neres, Jan Lars Rybniker, Benoit Lechartier, Shi-Yan Caroline Foo, Andréanne Lupien
Benzothiazinones (BTZs) are a class of compounds found to be extremely potent against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains. The potency of BTZs is explained by their specificity for their target decaprenylphosphoryl-D ...
American Society for Microbiology2016