Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Yves WeinandBiography
Architect and civil engineer, Prof. Dr. Yves Weinand is one of the most recognised researchers in the field of contemporary wood construction. Founder of the Bureau d'Etude Weinand, he has, since 1996, designed and worked on many emblematic wooden buildings, such as the Saint Loup Chapel, the new Vaudois Parliament or, more recently, the Timber Pavilion of Vidy in Lausanne. His fundamental research questions the technical and static possibilities of wooden materials. The interdisciplinary exploration carried out at the EPFL's Laboratory for Timber Constructions (Ibois), of which he is director, concerns wood in all its aspects, from round wood to manufactured wood. The recent research carried out at Ibois on free structures with wood-wood connections (without screw nor glue) has been the subject of several technological transfers, and stands as tangible proof of new possibilities for wood construction. Yves Weinand is currently working on a large-scale project for a hall for the head office of a joinery in Luxembourg, consisting of a succession of arches with spans of 22.5 to 53.7m, entirely assembled in wood ). Through new innovative approaches, the ambition of his research is to develop a new generation of renewable and ecological wooden construction.He is regularly invited to present his work at international symposia on timber construction.
Fields of expertise
Architectural designTimber structuresDigital FabricationRobotic AssemblyStructural Wood mechanicsIntegrally Attached Timber plate structures
Distinctions
2012 Grand Prix d'Architecture de Wallonie
2014 Best Paper Award, Advances in Architectural Geometry conference. (IBOIS team)
2017 Medal for Research and Technique by the Academy of Architecture. 2018 Mention Régionale, Prix Lignum for the Timber Pavilion of Vidy-Lausanne
2019 "Disctinction Bois 2019" for the Nouveau Parlement vaudois.2019 Grand Prix d'Architecture de Wallonie____________________________________________________________________________
Selected publications
Les Cahiers de l'Ibois/ Ibois Notebooks 1, F. Fromonot, S. Berthier, Y. Rocher, publication directors: Y. Weinand et C. Catsaros, 2020 EPFL Press Le Pavillon en bois du Théâtre de Vidy, under the direction of Yves Weinand; V. Baudriller, J. Gamerro, M. Jaccard, C. Robeller; 2017, PPURAdvanced Timber Structures - Architectural Designs and Digital Dimensioning, Y. Weinand, 2017, Birkhaüser, publié en trois langues (french : Structures Innovantes en Bois (2016); german : Neue Holztragwerke - Architektonische Entwürfe und digitale Bemessung (2017)Grubenmann Project / Projekt Grubenmann, Y. Weinand, 2016, Stiftung Grubenmann-SammlungTimber Project: Nouvelles formes d’architectures en bois, Y. Weinand, 2010, PPURArchitexto, Y. Weinand and D. Darcis, 2009, Editions Fourre-Tout, LiègeLe bois soudé, B. Stamm and Y. Weinand, 2004, Architecture Bois & DépendanceNew Modeling - projeter ensemble, Y. Weinand, 2003, PPUR Andreas MortensenAndreas Mortensen is currently Professor and Director of the Institute of Materials at the Swiss Federal Institute of Technology in Lausanne (EPFL), where he heads the Laboratory for Mechanical Metallurgy. He joined the faculty of EPFL 1997 after ten years, from 1986 to 1996, as a member of the faculty of the Department of Materials Science and Engineering at the Massachusetts Institute of Technology, where he held the successive titles of ALCOA Assistant Professor, Associate Professor, and Professor. His research is focussed on the processing, microstructural development and mechanical behavior of advanced metallic materials with particular focus on metal matrix composites and metal foams, on infiltration processing and capillarity, and on damage and fracture in metallic materials. He is author or co-author of two monographs, around one hundred and eighty scientific or technical publications and twelve patents. Born in San Francisco in 1957, of dual (Danish and US) nationality, Andreas Mortensen graduated in 1980 from the Ecole Nationale Supérieure des Mines de Paris with a Diplôme dIngénieur Civil, and earned his Ph.D. in the Department of Materials Science and Engineering at MIT in 1986. Besides his academic employment, he was a postdoctoral researcher at Nippon Steel during part of 1986, and was invited professor at the Ecole des Mines in Paris during the academic year 1995 to 1996. He is a member of the editorial committee of International Materials Reviews and has co-edited four books. He is a Fellow of ASM, a recipient of the Howe Medal and the Grossman Award of the American Society of Metals, was awarded the Péchiney Prize by the French Academy of Sciences and the Res Metallica Chair from the Katholieke Universiteit Leuven, received three EPFL teaching awards, is one of ISIs Highly Cited authors for Materials Science since 2002 and was awarded an ERC advanced grant in 2012.
Bernard MoretBernard M.E. Moret was born in Vevey, Switzerland, received baccalauréats in Latin-Greek and Latin-Mathematics, then did a Diploma in Electrical Engineering at EPFL. After working for 2 years for Omega and Swiss Timing on the development of real-time OS for sports applications, he left for the US. He received his PhD in Electrical Engineering from the U. of Tennessee in 1980 and joined the Department of Computer Science at the University of New Mexico (UNM) that fall. He served as Chairman of the department from 1991 till 1993 and eventually retired in summer 2006 to join the School of Computer and Communication Sciences at EPFL. (You can read about his work at UNM on his (archived) personal and laboratory web pages at UNM.) He was appointed group leader for phylogenetics at the Swiss Institute for Bioinformatics (SIB). From 2009 until his retirement, he was also in charge of the BS and MS programs in Computer Science and Associate Dean for Education. He founded the ACM Journal of Experimental Algorithmics (JEA) and served as its Editor-in-Chief for 7 years; he also helped found the IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB), where he served as Associate Editor until 2008. He founded the annual Workshop on Algorithms in Bioinformatics (WABI) and chairs its steering committee, and he serves on the steering committee of the Workshop on Algorithm Engineering and Experiments (ALENEX). Until summer 2008, he chaired the Biodata Management and Analysis (BDMA) study section of the US National Institutes of Health (NIH); now he is a charter member of the NIH College of Reviewers. He led a team of over 50 biologists, computer scientists, and mathematicians in the CIPRES (Cyber Infrastructure for Phylogenetic Research) project, funded by the US National Science Foundation (NSF) for US$ 12 million over 5 years. He has published nearly 150 papers in computational biology, under funding from the US NSF, the Alfred P. Sloan foundation, the IBM Corporation, the US NIH, the Swiss NSF, and SystemsX.ch. He is a Fellow of the ISCB (International Society for Computational Biology). His Erdös number is 2 and (as of 2020) his h-index is 48.
