Muzaffargarh District () is a district of the Punjab province of Pakistan. Its capital is Muzaffargarh city. It lies on the bank of the Chenab River.
The district is administratively divided into the following three tehsils (subdivisions), which contain a total of 93 Union Councils:
At the time of the 2017 census the district had a population of 4,328,549, of which 2,223,085 were males and 2,105,145 females. Rural population is 3,630,138 while the urban population is 698,411. The literacy rate was 47.11%.
As per the 2017 census, Muslims made up almost the entire population with 99.78%.
At the time of the 2017 census, 88.23% of the population spoke Saraiki, 5.66% Punjabi, 4.51% Urdu and 1.07% Pashto as their first language.
The most famous tribes and races are as under; Khar (offshoot of Kharal tribe), Khokhar, Dasti, Qureshi, Jatoi, Hinjra, Langrial, Thahim, Gopang, Bukhari, Gilani, Rajput, Jat and Arian. The major ethnic group are the Saraiki-speaking Jat forming the majority, with Saraiki-speaking Gujjar, Baloch, Rajputs and Pathans groups in minority.
Muzzaffargarh was an ancient settlement, inhabited by Mallian people of Multan region. Umayyad Arabs led by Muhammad ibn e Qasim conquered the area in early 8th century spreading Islam in the region.
In 997 CE, Sultan Mahmud Ghaznavi, took over the Ghaznavid dynasty empire established by his father, Sultan Sebuktegin, In 1005 he conquered the Shahis in Kabul in 1005, and followed it by the conquests of Punjab region. The Delhi Sultanate and later Mughal Empire ruled the region. The Punjab region became predominantly Muslim due to missionary Sufi saints whose dargahs dot the landscape of Punjab region.
Muzaffargarh region became a part of the Muslim Ghaurid Sultanate when the Persian noble Sultan Shahab-ud-Din Muhammad Ghauri conquered Punjab in 1185. The area slowly developed as medieval town and many Muslim Sufi missionaries converted the local population to Islam.
During the Mughal period population increased and land under cultivation increased.