Concept

Dose (biochemistry)

Related publications (48)

Fluid mechanics of intrathecal drug delivery

The aim of this principally experimental study is to understand from fluid mechanic principles why an insignificant anesthetic dose administered as a short bolus into the cerebrospinal fluid inside the subarachnoid space provides greater pain relief than a ...

EPFL2008

Irradiation creep and precipitation in a ferritic ODS steel under helium implantation

Manuel Alexandre Pouchon, Wolfgang Hoffelner

Ferritic oxide dispersion strengthened (ODS) steel, PM2000, has been homogeneously implanted with helium under uniaxial tensile stresses from 20 to 250 MPa to maximum doses of about 0.75 dpa (3000 ppm He) with displacement damage rates of 5.5 × 10−6 dpa/s ...

Elsevier2008

Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model

Ming Zhang

Availability of an ultra-short-course drug regimen capable of curing patients with tuberculosis in 2 to 3 mo would significantly improve global control efforts. Because immediate prospects for novel treatment-shortening drugs remain uncertain, we examined ...

2007

Photothrombic activity of m-THPC-loaded liposomal formulations: pre-clinical assessment on chick chorioallantoic membrane model

Hubert van den Bergh, Georges Wagnières, Elodie Debefve

The objective of this study was to evaluate the ability of meso-tetra(hydroxyphenyl)chlorin (m-THPC) encapsulated into liposomal formulations to occlude neovascularization. Two m-THPC formulations including conventional or plain liposomes (Foslip) based on ...

Elsevier2006

The role of cisplatin and NAMI-A plasma-protein interactions in relation to combination therapy

Paul Joseph Dyson, Gianni Sava

The aim of the study is to evaluate the differences of protein binding of NAMI-A, a new ruthenium drug endowed with selective antimetastatic properties, and of cisplatin and to ascertain the possibility to use two drugs based on heavy metals in combination ...

2006

Temperature dependence of irradiation effects in pure titanium

Nadine Baluc

The microstructural modifications due to irradiation in hcp pure metals and their consequences on the mechanical properties have been investigated. Experimental results for proton-irradiated pure polycrystalline titanium are presented and discussed. Sample ...

2005

Phasing in the presence of severe-site specific radiation damage through dose-dependent modelling of heavy atoms

The case of a brominated RNA crystal structure determination in which standard three-wavelength MAD phasing was unsuccessful because of fast X-ray-induced debromination was reinvestigated [Ennifar et al. ( 2002), Acta Cryst. D58, 1262 - 1268]. It was found ...

2004

Effects of dinoseb on the life cycle of Daphnia magna : modeling survival time and a proposal for an alternative to the no-observed-effect concentration

Joseph Tarradellas, Kristin Becker van Slooten, Renata Behra

Risk assessment is in urgent need of more accurate toxic effect endpoints than those currently in use, especially for low concentrations. Often such endpoints are estimated by analysis of variance, linear interpolation, or smoothing. As these statistical m ...

2002

Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia

Patrick Aebischer, Bernard Schneider

BACKGROUND: Existing animal models of anemia inadequately reflect the hematocrit usually present in chronic renal failure (CRF) patients and do not permit long-term treatment studies. The transgenic mouse strain 134.3LC (Epo-TAg(H)) displays a severe chron ...

2002

Routine experimental system for defining conditions used in photodynamic therapy and fluorescence photodetection of (non-) neoplastic epithelia

Hubert van den Bergh, Pavel Kucera

A common method to induce enhanced short-term endogenous porphyrin synthesis and accumulation in cell is the topical, systemic application of 5-aminolevulinic acid or one of its derivatives. This circumvents the intravenous administration of photosensitize ...

2001

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