Christian EnzChristian C. Enz (M84, S'12) received the M.S. and Ph.D. degrees in Electrical Engineering from the EPFL in 1984 and 1989 respectively. From 1984 to 1989 he was research assistant at the EPFL, working in the field of micro-power analog IC design. In 1989 he was one of the founders of Smart Silicon Systems S.A. (S3), where he developed several low-noise and low-power ICs, mainly for high energy physics applications. From 1992 to 1997, he was an Assistant Professor at EPFL, working in the field of low-power analog CMOS and BiCMOS IC design and device modeling. From 1997 to 1999, he was Principal Senior Engineer at Conexant (formerly Rockwell Semiconductor Systems), Newport Beach, CA, where he was responsible for the modeling and characterization of MOS transistors for the design of RF CMOS circuits. In 1999, he joined the Swiss Center for Electronics and Microtechnology (CSEM) where he launched and lead the RF and Analog IC Design group. In 2000, he was promoted Vice President, heading the Microelectronics Department, which became the Integrated and Wireless Systems Division in 2009. He joined the EPFL as full professor in 2013, where he is currently the director of the Institute of Microengineering (IMT) and head of the Integrated Circuits Laboratory (ICLAB).He is lecturing and supervising undergraduate and graduate students in the field of Analog and RF IC Design at EPFL. His technical interests and expertise are in the field of very low-power analog and RF IC design, semiconductor device modeling, and inexact and error tolerant circuits and systems.He has published more than 200 scientific papers and has contributed to numerous conference presentations and advanced engineering courses. Together with E. Vittoz and F. Krummenacher he is one of the developer of the EKV MOS transistor model and the author of the book "Charge-Based MOS Transistor Modeling - The EKV Model for Low-Power and RF IC Design" (Wiley, 2006). He has been member of several technical program committees, including the International Solid-State Circuits Conference (ISSCC) and European Solid-State Circuits Conference (ESSCIRC). He has served as a vice-chair for the 2000 International Symposium on Low Power Electronics and Design (ISLPED), exhibit chair for the 2000 International Symposium on Circuits and Systems (ISCAS) and chair of the technical program committee for the 2006 European Solid-State Circuits Conference (ESSCIRC). Since 2012 he has been elected as member of the IEEE Solid-State Circuits Society (SSCS) Administrative Commmittee (AdCom). He is also Chair of the IEEE SSCS Chapter of Switzerland.
Mihai Adrian IonescuAdrian M. Ionescu is Full Professor at the Swiss Federal Institute of Technology, Lausanne, Switzerland. He received the B.S./M.S. and Ph.D. degrees from the Polytechnic Institute of Bucharest, Romania and the National Polytechnic Institute of Grenoble, France, in 1989 and 1997, respectively. He has held staff and/or visiting positions at LETI-CEA, Grenoble, France and INP Grenoble, France and Stanford University, USA, in 1998 and 1999. Dr. Ionescu has published more than 600 articles in international journals and conferences. He received many Best Paper Awards in international conferences, the Annual Award of the Technical Section of the Romanian Academy of Sciences in 1994 and the Blondel Medal in 2009 for contributions to the progress in engineering sciences in the domain of electronics. He is the 2013 recipient of the IBM Faculty Award in Engineering. He served the IEDM and VLSI conference technical committees and was the Technical Program Committee (Co)Chair of ESSDERC in 2006 and 2013. He is a member of the SATW. He is director of the Laboratory of Micro/Nanoelectronic Devices (NANOLAB).
Mario PaoloneMario Paolone received the M.Sc. (with honors) and the Ph.D. degree in electrical engineering from the University of Bologna, Italy, in 1998 and 2002, respectively. In 2005, he was appointed assistant professor in power systems at the University of Bologna where he was with the Power Systems laboratory until 2011. In 2010, he received the Associate Professor eligibility from the Politecnico di Milano, Italy. Since 2011 he joined the Swiss Federal Institute of Technology, Lausanne, Switzerland, where he is now Full Professor, Chair of the Distributed Electrical Systems laboratory and Head of the Swiss Competence Center for Energy Research (SCCER) FURIES (Future Swiss Electrical infrastructure). He was co-chairperson of the technical programme committees of the 9th edition of the International Conference of Power Systems Transients (IPST 2009) and of the 2016 Power Systems Computation Conference (PSCC 2016). He was chair of the technical programme committee of the 2018 Power Systems Computation Conference (PSCC 2018). In 2013, he was the recipient of the IEEE EMC Society Technical Achievement Award. He was co-author of several papers that received the following awards: best IEEE Transactions on EMC paper award for the year 2017, in 2014 best paper award at the 13th International Conference on Probabilistic Methods Applied to Power Systems, Durham, UK, in 2013 Basil Papadias best paper award at the 2013 IEEE PowerTech, Grenoble, France, in 2008 best paper award at the International Universities Power Engineering Conference (UPEC). He was the founder Editor-in-Chief of the Elsevier journal Sustainable Energy, Grids and Networks and was Associate Editor of the IEEE Transactions on Industrial Informatics. His research interests are in power systems with particular reference to real-time monitoring and operation, power system protections, power systems dynamics and power system transients. Mario Paolone is author or coauthor of over 300 scientific papers published in reviewed journals and international conferences.
Maher KayalMaher Kayal received M.S. and Ph.D degrees in electrical engineering from the Ecole Polytechnique Fédérale de Lausanne (EPFL, Switzerland) in 1983 and 1989 respectively. He has been with the Electronics laboratories of the Ecole Polytechnique Fédérale de Lausanne (EPFL, Switzerland) since 1990, where he is currently a professor and director of the Energy Management and Sustainability" section. He has published many scientific papers, coauthor of three text books dedicated to mixed-mode CMOS design and he holds eleven patents. His technical contributions have been in the area of analog and Mixed-signal circuits design including highly linear and tunable sensors microsystems, signal processing and green energy management.
Prizes and Honors
Electronics Letters journal Premium Award 2013,
Outstanding Paper Award? IEEE Mixdes 2013
Basil Papadias paper Award, IEEE Powertech 2013
Best Paper Awards, Mixdes 2013
Best Paper Awards, ICCAS 2012
Outstanding Paper Award- IEEE Mixdes 2012.
Poland Section IEEE ED Chapter special award in 2011.
Credit Suisse Award for Best Teaching- 2009.
The William M. Portnoy Award at the Energy Conversion Congress and Exposition , California Sept 2009.
Best Paper Award - IEEE-Mixdes 2009.
High Quality Paper - IEEE Power Tech Conference June 2009.
Best Paper Award - IEEE-Mixdes 2007.
Best Paper Award - IEEE-TTTC International Conference on Automation, Quality and Testing, Robotics - 2006.
Best Application Specific Integrated Circuit at the International European Design and Test Conference ED&TC - 1997.
Ascom Award for the Best Work in Telecommunication Fields 1990.
Publications Books.
Books:
Methodology for the Digital Calibration of Analog Circuits and Systems, Marc Pastre & Maher Kayal. Springer Publisher- (ISBN 1-4020-4252-3)-2006.
Structured Analog CMOS Design, Danica Stefanovic & Maher Kayal. Springer Publisher-(ISBN 978-1-4020-8572-7)-2008.
Linear CMOS RF Amplifiers for Wireless Applications, Maher Kayal, Springer Publisher. (ISBN 978-90-481-9360-8)-2010.
Coeditor of Microelectronics Education Kluwer Academic Publishers. (ISBN 1-4020-2072-4). -2004.
Alfred RuferOriginaire de Diessbach (BE), Alfred Rufer est né en 1951. Il obtient en 1976 le diplôme d'ingénieur électricien de l'EPFL et poursuit son activité dans le même établissement en tant qu'assistant à la chaire d'électronique industrielle. En 1993, il est nommé professeur-assistant au Laboratoire d'électronique industrielle. Au début 1996, il est nommé professeur extraordinaire. En 1978, il débute son activité dans l'industrie de l'électronique de grande puissance à la société ABB, Asea Brown Boveri à Turgi, où il contribue au développement d'entraînements réglés à fréquence variable. Dès 1985, il exerce la fonction d'assistant technique et de chef de groupe. De 1988 à 1991, il poursuit le développement de nouveaux systèmes d'électronique de puissance dans différents domaines d'application. A. Rufer est l'auteur et co-auteur de plusieurs demandes de brevet, ainsi que de plusieurs publications. De 1991 à 1992, il est chef d'un département de développement d'appareils d'électronique de réglage et de commande pour l'électronique de puissance. Durant son activité professionnelle dans l'industrie, il participe activement à l'enseignement technique dans plusieurs écoles d'ingénieurs.
Sandro CarraraSandro Carrara is an IEEE Fellow for his outstanding record of accomplishments in the field of design of nanoscale biological CMOS sensors. He is also the recipient of the IEEE Sensors Council Technical Achievement Award in 2016 for his leadership in the emerging area of co-design in Bio/Nano/CMOS interfaces. He is a Professor of the EPFL in Lausanne (Switzerland), and head of the "Bio/CMOS Interfaces" (BCI) research group. He is former professor of optical and electrical biosensors at the Department of Electrical Engineering and Biophysics (DIBE) of the University of Genoa (Italy) and former professor of nanobiotechnology at the University of Bologna (Italy). He holds a PhD in Biochemistry & Biophysics from University of Padua (Italy), a Master degree in Physics from University of Genoa (Italy), and a diploma in Electronics from National Institute of Technology in Albenga (Italy). His scientific interests are on electrical phenomena of nano-bio-structured films, and include CMOS design of biochips based on proteins and DNA. Along his carrier, he published 7 books, one as author with Springer on Bio/CMOS interfaces and, more recently, a Handbook of Bioelectronics with Cambridge University Press. He has more than 250 scientific publications and is author of 13 patents. He is now Editor-in-Chief of the IEEE Sensors Journal, the largest journal among 2019 IEEE publications; he is also founder and Editor-in-Chief of the journal BioNanoScience by Springer, and Associate Editor of IEEE Transactions on Biomedical Circuits and Systems. He is a member of the IEEE Sensors Council and his Executive Committee. He was a member of the Board of Governors (BoG) of the IEEE Circuits And Systems Society (CASS). He has been appointed as IEEE Sensors Council Distinguished Lecturer for the years 2017-2019, and CASS Distinguished Lecturer for the years 2013-2014. His work received several international recognitions: several Top-25 Hottest-Articles (2004, 2005, 2008, 2009, and two times in 2012) published in highly ranked international journals such as Biosensors and Bioelectronics, Sensors and Actuators B, IEEE Sensors journal, and Thin Solid Films; a NATO Advanced Research Award in 1996 for the original contribution to the physics of single-electron conductivity in nano-particles; six Best Paper Awards at the IEEE Sensors Conference 2019 (Montreal) in 2019, Conferences IEEE NGCAS in 2017 (Genoa), MOBIHEALTH in 2016 (Milan), IEEE PRIME in 2015 (Glasgow), in 2010 (Berlin), and in 2009 (Cork); three Best Poster Awards at the EMBEC Conference in 2017 (Tampere, Finland), Nanotera workshop in 2011 (Bern), and NanoEurope Symposium in 2009 (Rapperswil). He also received the Best Referees Award from the journal Biosensor and Bioelectronics in 2006. From 1997 to 2000, he was a member of an international committee at the ELETTRA Synchrotron in Trieste. From 2000 to 2003, he was scientific leader of a National Research Program (PNR) in the filed of Nanobiotechnology. He was an internationally esteemed expert of the evaluation panel of the Academy of Finland in a research program for the years 2010-2013. He has been the General Chairman of the Conference IEEE BioCAS 2014, the premier worldwide international conference in the area of circuits and systems for biomedical applications
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
