Concept

Abnormality (behavior)

Related publications (29)

Involvement of prelimbic cortex neurons and related circuits in the acquisition of a cooperative learning by pairs of rats

Maria del Carmen Sandi Perez, Elias Georges Gebara, Ana del Rocio Conde Moro

Social behaviors such as cooperation are crucial for mammals. A deeper knowledge of the neuronal mechanisms underlying cooperation can be beneficial for people suffering from pathologies with impaired social behavior. Our aim was to study the brain activit ...

Springer2024

Thermal conductivity of Li 3 PS 4 solid electrolytes with ab initio accuracy

Michele Ceriotti, Federico Grasselli

The vast amount of computational studies on electrical conduction in solid-state electrolytes is not mirrored by comparable efforts addressing thermal conduction, which has been scarcely investigated despite its relevance to thermal management and (over)he ...

Amer Physical Soc2024

Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential

Lijing Xin, Kim Do, Daniella Dwir

Redox biology and immune signaling play major roles in the body, including in brain function. A rapidly growing literature also suggests that redox and immune abnormalities are implicated in neuropsychiatric conditions such as schizophrenia (SZ), bipolar d ...

OXFORD UNIV PRESS2023

Glucocorticoid-based pharmacotherapies preventing PTSD

Maria del Carmen Sandi Perez, Silvia Monari

Posttraumatic stress disorder (PTSD) is a highly disabling psychiatric condition that may arise after exposure to acute and severe trauma. It is a highly prevalent mental disorder worldwide, and the current treatment options for these patients remain limit ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function

Maria del Carmen Sandi Perez, Bernard Schneider, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Elias Georges Gebara, Marie-Isabelle Guillot de Suduiraut, Alessandro Chioino, Sriparna Ghosal, Eva Ramos Fernandez

The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with social competitiveness, and the mitochondrial fusion protein mitofusin 2 (Mfn2) in NAc neurons ...

2023

Study of brain metabolic dysfunctions in animal models of mood disorder using magnetic resonance spectroscopy

Antoine Timothée Cherix

Mood disorders, in particular depression, are a major burden of our society. Due to the poor knowledge of the biological basis of these diseases, classification remains based on arbitrary symptomatic parameters. As a result, the existing pharmacological tr ...

EPFL2020

Peripubertal stress-induced heightened aggression: modulation of the glucocorticoid receptor in the central amygdala and normalization by mifepristone treatment

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Stamatina Tzanoulinou, Orbicia Riccio Wicht, Vandana Veenit

Despite the enormous negative impact of excessive aggression for individuals and societies, there is a paucity of treatments. Here, using a peripubertal stress model of heightened aggression in rats, we investigated the involvement of the glucocorticoid sy ...

2019

Impact of individual differences in glucocorticoid adaptation to stress on behavior, neurophysiology and metabolism

Damien Sébastien Huzard

The stress system is a key modulator of homeostasis and allows organisms to adapt to environmental changes. Proper survival is dependent on the appropriate stress response, for example initiating food (energy) intake or provoking physical reaction. However ...

EPFL2018

The programming of the social brain by stress during childhood and adolescence: from rodents to humans

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou

The quality and quantity of social experience is fundamental to an individual's health and well-being. Early life stress is known to be an important factor in the programming of the social brain that exerts detrimental effects on social behaviors. The peri ...

Springer2017

Constitutive differences in habituation of the glucocorticoid response to stress are related to variation in aggression and anxiety-related behaviors

Maria del Carmen Sandi Perez, Olivia Zanoletti, Marie-Isabelle Guillot de Suduiraut, Sophie Elizabeth Walker

Glucocorticoids coordinate responses that enable an individual to cope with stressful challenges and, additionally, mediate adaptation following cessation of a stressor. There are important individual differences in the magnitude of glucocorticoid responsi ...

2017

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