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Nuclear magnetic resonance (NMR) is a non-invasive tool for the study of human diseases. In particular, carbon-13 magnetic resonance spectroscopy (13C MRS) is a promising derivative tool for investigating metabolism in vivo, as it allows the non-invasive m ...
Cholesterol is a very crucial lipid for animal cells, since it is the building block of cellular membranes, control fluidity of membranes, regulate intracellular transport, cell signalling, nerve conduction and serve as a precursor for synthesis of vitamin ...
Determining the conformation of biological molecules is key for understanding their function. The recent combination of mass spectrometry, cryogenic ion traps, and laser spectroscopy is providing new methods to interrogate individual conformations of pepti ...
Background: The RCSB Protein Data Bank (PDB) provides public access to experimentally determined 3D-structures of biological macromolecules (proteins, peptides and nucleic acids). While various tools are available to explore the PDB, options to access the ...
Purpose The macromolecule signal plays a key role in the precision and the accuracy of the metabolite quantification in short-TE 1H MR spectroscopy. Macromolecules have been reported at 1.5 Tesla (T) to depend on the cerebral studied region and to be age s ...
Nanostructures are promising candidates for use as active materials for the detection of chemical and biological species, mainly due to the high surface-to-volume ratio and the unique physical properties arising at the nanoscale. Among the various nanostru ...
Nanostructures are promising candidates for use as active materials for the detection of chemical and biological species, mainly due to the high surface-to-volume ratio and the unique physical properties arising at the nanoscale. Among the various nanostru ...
Recent discoveries in the field of innate immunity have highlighted the existence of a family of nucleic acid-sensing proteins that have similar structural and functional properties. These include the well-known oligoadenylate synthase (OAS) family protein ...
The application of macrocycles to previously undruggable targets has aroused a great deal of interest in this structural class. Recent studies advance our understanding of the way macrocycles bind protein targets and provide new strategies and tools to gen ...
Current thesis is devoted to the investigation of biopolymers using AFM, a well established and widely used technique. To begin with, we studied processing of AFM images and its automation. Our software product, DNA Trace, permit one to quickly extract sci ...