Concept
T-cell prolymphocytic leukemia
Related publications (13)
Caspase-9-mediated cleavage of vimentin attenuates the aggressiveness of leukemic NB4 cells
Cyrus Kazemiraad, Saeed Mohammadi
Vimentin is a main type 3 intermediate filament protein. It seems that abnormal expression of vimentin is contributed to the appearance of the aggressive feature of cancer cells. So that it has been reported that malignancy and epithelial-mesenchymal trans ...
SPRINGER2023Notch signaling promotes disease initiation and progression in murine chronic lymphocytic leukemia
Freddy Radtke, Ute Koch, Nadine Fournier, Jessica Sordet, Marianne Nkosi, Delphine Maude Tardivon, Mateusz Waldemar Antoszewski
NOTCH1 gain-of-function mutations are recurrent in B-cell chronic lymphocytic leukemia (B-CLL), where they are associated with accelerated disease progression and refractoriness to chemotherapy. The specific role of NOTCH1 in the development and progressio ...
AMER SOC HEMATOLOGY2021Notch Signaling - a Booster of Chronic Lymphocytic Leukemia During Initiation and Disease Progression
Chronic lymphocytic leukemia (CLL) is a B cell malignancy and represents the most common leukemia in adults within the Western world. This disease mainly affects the elderly, with a median age of diagnosis over 70. The disease course is highly variable amo ...
EPFL2020Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia
Filipe Amândio Brandão Sanches Vong Martins
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases, with a variable probability of transformation into acute leukemia, which is, in the vast majority of cases, of myeloid lineage. Nevertheless, rare cases of acute lymphoblastic leukemia ...
SPRINGER2020