Concept

Subgranular zone

Related publications (97)

Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells

Notch1 regulates neural stem cell (NSC) number during development, but its role in adult neurogenesis is unclear. We generated nestin-CreER(T2)/R26R-YFP/Notch1(loxP/loxP) [Notch1inducible knock-out (iKO)] mice to allow tamoxifen (TAM)-inducible elimination ...

Society for Neuroscience2010

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors

Maria del Carmen Sandi Perez, Hilal Lashuel, Hajer Ouertatani-Sakouhi

Intensive research is devoted to unravel the neurobiological mechanisms mediating adult hippocampal neurogenesis, its regulation by antidepressants, and its behavioral consequences. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokin ...

Nature Publishing Group2010

Pro-neurogenesis therapy rescues hippocampal-mediated learning and memory deficits in the ts65dn mouse model of Down syndrome

Diego Ghezzi

Down syndrome (DS) is the most frequent cause of mental retardation in adults and children. It has been proposed that cognitive disabilities associated with DS may be ascribed to neurogenesis impairment during both development and adulthood. This view is s ...

2010

Neurogenesis as therapeutic target to rescue hippocampal-mediated learning and memory deficits in a mouse model of Down syndrome

Diego Ghezzi

Down syndrome (DS) is the most frequent cause of cognitive disability in children and adults. It has been reported that defects in neurogenesis occur both during development and adulthood and possibly underlie cognitive dysfunction associated with DS. Rece ...

2010

Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Guillaume Poirier, Cristina Marquez Vega, Jorge Eduardo Castro Cifuentes

The stimulation of adult hippocampal neurogenesis by antidepressants has been associated with multiple molecular pathways, but the potential influence exerted by other brain areas has received much less attention. The basolateral complex of the amygdala (B ...

Public Library of Science2010

Effect of Model Accuracy on the Result of Computed Current Densities in the Simulation of Transcranical Magnetic Stimulation

Juan Ramon Mosig, Michael Mattes, Laleh Golestanirad

One of the most hindering limitations in the simulation of a realistic biological system is the complexity of the model which may easily lead to a very heavy computational burden. This may seriously question the possibility of optimizing system parameters ...

Institute of Electrical and Electronics Engineers2010

Neurite guidance through 3D hydrogel layers in a microfluidic environment

Philippe Renaud, Robert Meissner, Anja Kunze

Neuronal cell culture models in vitro are often restricted to 2D surfaces. Engineering the complexity of the neuronal microenvironment in microfluidic systems can help to generate more tissue like cultures. We have developed a new neuronal cell culturing s ...

2010

Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability

Pierre Magistretti, Hilal Lashuel, Igor Allaman, Thierry Laroche, David Viertl

Amyloid-beta (Abeta) peptides play a key role in the pathogenesis of Alzheimer's disease and exert various toxic effects on neurons; however, relatively little is known about their influence on glial cells. Astrocytes play a pivotal role in brain homeostas ...

2010

High-throughput methods to define complex stem cell niches

Matthias Lütolf, Stefan Kobel

The potential of stem cells in clinics and as a diagnostic tool is still largely unmet, partially due to a lack of in vitro models that efficiently mimic the in vivo stem cell microenvironment—or niche—and thus would allow reproducible propagation of stem ...

2010

A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells

David Michael Suter

The transcription factors Sox1 and Pax6 are expressed sequentially during early mouse embryonic neurogenesis. Sox1 expression starts upon formation of neuroectoderm, whereas Pax6 is subsequently expressed in radial glial cells, the latter giving rise to mo ...

2009

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