Publications related to DNA methylation

Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems

Melanie Blokesch, David William Adams, Alexandre Lemopoulos, Grazia Vizzarro

In response to predation by bacteriophages and invasion by other mobile genetic elements such as plasmids, bacteria have evolved specialised defence systems that are often clustered together on genomic islands. The O1 El Tor strains of Vibrio cholerae resp ...

2024

Micropreparative Gel Electrophoresis for Purification of Nanoscale Bioconjugates

Ardemis Anoush Boghossian, Yahya Rabbani, Shang-Jung Wu, Vitalijs Zubkovs, Sayyed Hashem Sajjadi

Conventional techniques for purifying macromolecular conjugates often require complex and costly installments that are inaccessible to most laboratories. In this work, we develop a one-step micropreparative method based on a trilayered polyacrylamide gel e ...

2024

Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

Didier Trono, Evaristo Jose Planet Letschert, Wayo Matsushima

Growing evidence indicates that transposable elements (TEs) play important roles in evolution by providing genomes with coding and non-coding sequences. Identification of TE-derived functional elements, however, has relied on TE annotations in individual s ...

2024

Molecular mechanism of plasmid elimination by the DdmDE defense system

Melanie Blokesch, Sandrine Stutzmann, David William Adams, Laurie Righi

Seventh pandemic Vibrio cholerae strains contain two pathogenicity islands that encode the DNA defense modules DdmABC and DdmDE. Here we use cryogenic electron microscopy to reveal the mechanistic basis for plasmid defense by DdmDE. A structure of the DdmD ...

2024

Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis

Maria del Carmen Sandi Perez, Mandy Meijer

DNA methylation (DNAm) is one of the most frequently studied epigenetic mechanisms facilitating the interplay of genomic and environmental factors, which can contribute to externalizing behaviours and related psychiatric disorders. Previous epigenome-wide ...

PERGAMON-ELSEVIER SCIENCE LTD2023

DNA modifications impact natural transformation of Acinetobacter baumannii

Melanie Blokesch, Nicolas Jean Philippe Guex, Christian Iseli, Alexandre Lemopoulos, Nina Vesel

Acinetobacter baumannii is a dangerous nosocomial pathogen, especially due to its ability to rapidly acquire new genetic traits, including antibiotic resistance genes (ARG). In A. baumannii, natural competence for transformation, one of the primary modes o ...

2023

A field-capable rapid plant DNA extraction protocol using microneedle patches for botanical surveying and monitoring

Sebastian Maerkl, Nicolas Rémi Adam, Jonathan Selz

PremiseA novel protocol for rapid plant DNA extraction using microneedles is proposed, which supports botanic surveys, taxonomy, and systematics. This protocol can be conducted in the field with limited laboratory skills and equipment. The protocol is vali ...

WILEY2023

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

Denis Duboule, Alexandre Gauthier Aurèle Mayran, Hocine Rekaik, Lucille Delisle, Aurélie Hintermann, Célia Corinne Renée Bochaton

Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed tr ...

NATURE PORTFOLIO2023

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DNA methylation

Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems

Micropreparative Gel Electrophoresis for Purification of Nanoscale Bioconjugates

Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

Molecular mechanism of plasmid elimination by the DdmDE defense system

Inheritance of H3K9 methylation regulates genome architecture in Drosophila early embryos

Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis

DNA modifications impact natural transformation of Acinetobacter baumannii

DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study

A field-capable rapid plant DNA extraction protocol using microneedle patches for botanical surveying and monitoring

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

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Micropreparative Gel Electrophoresis for Purification of Nanoscale Bioconjugates

Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems

Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

Inheritance of H3K9 methylation regulates genome architecture in Drosophila early embryos

Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

DNA modifications impact natural transformation of Acinetobacter baumannii

Molecular mechanism of plasmid elimination by the DdmDE defense system

DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study

A field-capable rapid plant DNA extraction protocol using microneedle patches for botanical surveying and monitoring