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Nestin-Cre mice are widely used to generate gene deletions in the developing brain. Surprisingly, fewNestin-Cre lines have been characterized for their temporal and brain region-specific recombination. In addition, some Nestin-Cre lines express Cre outside ...
A no. of promising synthetic catalysts for the hydrolytic degrdn. of RNA have been developed in recent years. Some of them show remarkable selectivity for pyrimidine nucleotides. The general problem of all these studies is to distinguish between real effec ...
As observed by variable-temperature and -pressure C-13 NMR, intramolecular carbonyl scrambling in Ir2Rh2(CO)(12) and Ir-4(CO)(11)(mu-SO2) proceeds via a 'change of basal face' mechanism. In both cases the site exchange process has a positive activation vol ...
Numerous studies have shown the neuroprotective and regenerative benefits of glial cell line-derived neurotrophic factor (GDNF) in animal models of PD. Brain delivery of GDNF can, however, be associated with limiting side-effects in both primates and PD pa ...
The increasing use of contrast agents in magnetic resonance imaging (MRI) for medical diagnosis is due to the ability, called relaxivity, of these paramagnetic compounds to accelerate the relaxation of the surrounding water proton spins. A new classical fo ...
Due to the ubiquitous presence of a Berry phase, in most cases of dynamical Jahn-Teller systems the symmetry of the vibronic ground state is the same as that of the original degenerate electronic state; As a single exception, the linear H x h icosahedral m ...
The spatial and time-reversal symmetries of excitons in quantum wires are discussed, including possible use in numerical computation. Particular attention is paid to the important case of a single symmetry plane (group C-s). Even in such a low symmetry cas ...
In all vertebrates, invariant left/right (L/R) positioning and organization of the internal viscera is controlled by a conserved pathway. Nodal, a member of the TGFbeta superfamily is a critical upstream component responsible for initiating L/R axis determ ...
We record double resonance spectra of the 4nu(1) band of jet-cooled C-13-methanol using single rotational state selection in the nu(1) fundamental and subsequent promotion of the selected molecules to the fourth vibrational level. We then detect transition ...
A strong de electric field dependence of the dielectric permittivity makes perovskite ferroelectrics promising materials for tunable microwave devices like phase shifters, tunable resonators, tunable filters etc. Dielectric loss is a crucial parameter for ...