Publications related to Epithelioid cell

Live-seq enables temporal transcriptomic recording of single cells

Bart Deplancke, Vincent Roland Julien Gardeux, Orane Josiane Guillaume-Gentil, Riccardo Dainese, Wanze Chen, Pernille Yde Rainer, Magda Zachara, Wouter Saelens

Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize cellular heterogeneity(1). However, scRNA-seq requires lysing cells, which impedes further molecular or functional analyses on the same cells. Here, we established Liv ...

NATURE PORTFOLIO2022

Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

John McKinney, Ophélie Rutschmann, Chiara Toniolo

Mycobacterium tuberculosis infection is initiated by the inhalation and implantation of bacteria in the lung alveoli, where they are phagocytosed by macrophages. Even a single bacterium may be sufficient to initiate infection. Thereafter, the clinical outc ...

AMER SOC MICROBIOLOGY2022

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

Andrea Ablasser, Muhammet Fatih Gülen, Vivek Vijay Thacker, Théo Nass, Martin Schaller, Kunal Sharma

COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications1,2. Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs 3–5). Although rapid induction of type I ...

2022

Primary data for EPFL thesis "Metabolic regulation of cytokinesis in Schizosaccharomyces pombe"

Özge Uysal Özdemir

All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...

EPFL Infoscience2022

A new paradigm for leprosy diagnosis based on host gene expression

Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Thyago Leal Calvo

Author summary Despite effective treatment, leprosy is still a significant public health issue in more than 120 countries, with more than 200 000 new cases yearly. The disease is caused mainly by Mycobacterium leprae, a slow-growing bacillus still uncultiv ...

PUBLIC LIBRARY SCIENCE2021

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

Johan Auwerx, Matthias Alexander Sokrates Stein, Julien Weber, Tasneem Arsiwala

Aims: Sirtuin 6 (Sirt6) is a NAD(+)-dependent deacetylase that plays a key role in DNA repair, inflammation and lipid regulation. Sirt6-null mice show severe metabolic defects and accelerated aging. Macrophage-foam cell formation via scavenger receptors is ...

2020

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

Francesco Stellacci, Ye Yang, Ahmet Bekdemir

We sought to develop a nanoparticle vehicle that could efficiently deliver small molecule drugs to target lymphocyte populations. The synthesized amphiphilic organic ligand-protected gold nanoparticles (amph-NPs) were capable of sequestering large payloads ...

2019

Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes

Nahal Mansouri, Sina Nassiri

Mesenchymal stromal/stem cell (MSC) therapy has shown promise in experimental models of idiopathic pulmonary fibrosis (IPF). The aim of this study was to test the therapeutic effects of extracellular vesicles produced by human BM MSCs (MEx) in a bleomycin- ...

AMER SOC CLINICAL INVESTIGATION INC2019

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Epithelioid cell

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Live-seq enables temporal transcriptomic recording of single cells

Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

Primary data for EPFL thesis "Metabolic regulation of cytokinesis in Schizosaccharomyces pombe"

A new paradigm for leprosy diagnosis based on host gene expression

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

Surface engineering of T cells with polymer nanoparticles to enhance drug delivery to the brain

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes

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Primary data for EPFL thesis "Metabolic regulation of cytokinesis in Schizosaccharomyces pombe"

A new paradigm for leprosy diagnosis based on host gene expression

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

Surface engineering of T cells with polymer nanoparticles to enhance drug delivery to the brain

Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes

Live-seq enables temporal transcriptomic recording of single cells