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Concept
Endometrioid tumor
Summary
Endometrioid tumors are a class of tumor characterized by a resemblance to endometrium/ endometrial carcinoma, and over a third of cases have focal squamous differentiation.
They are part of the surface epithelial tumor group of ovarian neoplasms (10–20% of which are the endometrioid type).
Benign and borderline variants are rare, as the majority are malignant.
There is an association with endometriosis and concurrent primary endometrial carcinoma (endometrial cancer).
On gross pathological examination, the tumor is cystic and may be solid and some arise in cystic endometriosis. In 40% of cases, endometrioid tumors are found bilaterally.
Endometrioid carcinoma can also arise in the endometrium.
Grades 1 and 2 are considered "type 1" endometrial cancer, while grade 3 is considered "type 2".
File:Pie chart of relative incidences of endometrial carcinoma.png|Relative incidences of [[endometrial carcinoma]]s by histopathology, being endometrioid in a majority of cases{{cite journal|last1=Mendivil|first1=Alberto|last2=Schuler|first2=Kevin M.|last3=Gehrig|first3=Paola A.|title=Non-Endometrioid Adenocarcinoma of the Uterine Corpus: A Review of Selected Histological Subtypes|journal=Cancer Control|volume=16|issue=1|year=2009|pages=46–52|issn=1073-2748|doi=10.1177/107327480901600107|pmid=19078929}}
Light microscopy shows tubular glands, resembling endometrium.
Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN gene mutation profiles. PTEN mutations are more frequent in low-grade endometrial endometrioid carcinomas (67%) compared with low-grade ovarian endometrioid carcinomas (17%). By contrast, CTNNB1 mutations are significantly different in low-grade ovarian endometrioid carcinomas (53%) compared with low-grade endometrial endometrioid carcinomas (28%). This difference in CTNNB1 mutation frequency may be reflective of the distinct tumoral microenvironments; the epithelial cells lining an endometriotic cyst within the ovary are exposed to a highly oxidative environment that promotes tumorigenesis.
Official source
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